Thymidine phosphorylase (TP) activation: convenience through innovation.
نویسندگان
چکیده
منابع مشابه
Blockade of paclitaxel-induced thymidine phosphorylase expression can accelerate apoptosis in human prostate cancer cells.
Recently, survival benefit by chemotherapy using paclitaxel (PTX) and the induction of thymidine phosphorylase (TP) by PTX have been reported in several solid tumors. On the other hand, TP confers antiapoptotic effect on tumor cells through inhibition of caspase-8 activation in vitro. On the basis of these previous observations, we hypothesized that (a) TP can be induced after PTX treatment in ...
متن کاملتعیین فعالیت آنزیم تیمیدین فسفریلاز گلبول‌های سفید و تیمیدین پلاسما در بیماران MNGIE به‌روش کروماتوگرافی مایع با کارایی بالا- فاز معکوس (RP-HPLC)
Background: Thymidine phosphorylase (TP) catalyses the conversion of thymidine into thymine. Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive disease which is caused by mutations in the nuclear gene encoding TP, bringing about severe impairment of TP-enzyme specific activity and accumulation of thymidine in plasma. The clinical manifestations of MNGIE are ...
متن کاملMNGIE with lack of skeletal muscle involvement and a novel TP splice site mutation.
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive multisystem disorder caused by thymidine phosphorylase (TP) deficiency, resulting in severe gastrointestinal dysmotility and skeletal muscle abnormalities. A patient is reported with a classical MNGIE clinical presentation but without skeletal muscle involvement at morphological, enzymatic, or mitochondrial ...
متن کاملThymidine phosphorylase activates NFκB and stimulates the expression of angiogenic and metastatic factors in human cancer cells
Thymidine phosphorylase (TP) promotes angiogenesis and metastasis, and confers resistance to anticancer agents in some cancer cell types. We previously reported that TP stimulates the expression of interleukin (IL)-8 in human KB cancer cells by an unknown mechanism. A mutation in the nuclear factor (NF)κB binding site of the IL-8 promoter suppressed promoter activity in KB/TP cells that overexp...
متن کاملMolecular basis for the involvement of thymidine phosphorylase in cancer invasion.
Thymidine phosphorylase (TP), also known as platelet-derived endothelial cell growth factor (PD-ECGF), has been implicated in bladder cancer angiogenesis and invasion. However, the molecular basis of its role in invasion remains unclear. We investigated the expression of TP and 10 invasion-related genes in bladder cancers from 72 randomly selected patients by real-time two-step RT-PCR assay. We...
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عنوان ژورنال:
- The oncologist
دوره 6 Suppl 4 شماره
صفحات -
تاریخ انتشار 2001